I have noticed that one account has recently stopped posting due to downvotes from a large orca account, and I just noticed another account being downvoted a few days ago. I believe it will be the same MO; the latest account to receive downvotes will eventually be forced to stop posting because they can not take it any longer.
I've seen this happening every once in a while. It has an impact on how active some people are on the blockchain, and on their sentiments. And that's especially hard for newcomers.
However, I do see a case where I agree with a downvoter, even if I rarely downvote myself (but I can skip upvoting). That's when someone uses alt accounts to mine rewards through comments, sometimes commenting with multiple alts on posts where they are likely to receive upvotes, and withdrawing most of the rewards regularly. And here I'm thinking more about the fact that these kind of comments rarely bring any value to the post they are commenting on, even though others may dislike the deceptive farming operation more.