The age old "eat an elephant one piece at a time". No one ever tells you that there's a freezer you can put the pieces of the elephant in, and focus on the most perishable bits first. :)
The one thing I hate about the task lists that are often given at work, often by disoganised managers, is that everything has a top priority, and it is the employee that needs to sit down with the manager and say:
"What is the real priority, because if everything is a priority, nothing is."