I use a local cousin of this plant, to great peripheral neuropathy in my big toes. At first, I could not feel anything from the plant touching the end of my toes.. And the random pains that would send me to laying on my back and breathing deep.. Like somebody driving nails into my toes.. They continued... But day by day, the plant began to give a feeling of tingles and then a little bit of pricking pain... And the much worse pain stopped happening. It has been about five years and it only returned a little bit, once... And I made another few treatments with "nettles" in English.."ortigas" in Spanish... And that was about a year and a half ago.. With no pains now.